A mutual exchange: Synthesizing aryl sulfides from non-smelling, non-toxic compounds

The importance of aryl sulfides in biologically active compounds has led chemists to develop methods to synthesize them from carbon-sulfur bond forming reactions. The conventional reaction, however, uses thiols that are foul-smelling and toxic. Now, chemists report a novel, thiol-free synthesis technique comprising a nickel-catalyzed aryl exchange between 2-pyridyl sulfide and aromatic esters, providing a versatile and inexpensive technology for both scientific and industrial applications.

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